Our Solutions for Transformative Patient Outcomes
Regeneration
This technology has the potential to revolutionize brain regeneration it uses patented technology to stimulate growth of patients’ own stem cells, then migrates them to the site of brain injury. These cells mature into new functional neurons, repair the injury, and restore function
Technology Overview
The technology leverages the use of bi-phasic electrical stimulation to target areas of the brain for the migration of endogenous neural progenitor cells (NPC) to the site of damaged or diseased cells for the restoration of neural connections as a treatment for neurological disorders and injuries, such as Parkinson’s disease, Alzheimer’s disease and stroke. This form of neurostimulation, like deep brain stimulation, generally involves implanting two electrodes in the brain. One electrode is implanted near the subventricular zone (SVZ) of the lateral ventricle (LV) where NPCs reside and the other electrode at the site of the damaged tissue and connected to a neurostimulator. Once activated, electrical currents flow between the electrodes into the surrounding tissue, creating an electric field.
Pre-clinical testing of the technology in stroke models has shown that murine NPC survival, migration and differentiation can be modified by an electric field. Biphasic stimulation, which works by alternating the direction of the electrical charge between positive and negative resulting in zero net charge in the tissue, has the potential to allow for greater flexibility in adjusting stimulation parameters and in optimizing therapeutic outcomes while reducing the risk of unintended tissue damage or electrode corrosion generally associated with prolonged unidirectional stimulation.
Our Neural Regeneration Technology defeats multiple stem cell therapy roadblocks and is widely applicable Consistent and Reliable Stimulates growth of patient’s own stem cells — no manufacture or injection of stem cells, or manufacture of large number of stem cells is needed. This removes significant ethical and technical hurdles that have plagued stem cell therapies. No Safety or ethical concerns Patient is stimulated to produce their own stem cells in the brain as an outcome of therapy. Externally sourced stem cells, and the safety and ethical roadblocks that go with them are not needed. It is a platform technology to treat multiple indications.